Title:
Dose Response Effect of Almonds on Selected Coronary Risk Factors

Summary:
Frequent consumption of nuts may lower the risk of cardiovascular disease by favorably altering serum lipid and lipoprotein concentrations. We compared the effects of 2 amounts of almond intake with those of a National Cholesterol Education Program (NCEP) Step I diet on serum lipids, lipoproteins, and glucose in healthy and mildly hypercholesterolemic adults.. In a randomized crossover design, 25 healthy subjects (14 men, 11 women) with a mean (± SD) age of 41 ± 13 y were fed 3 isoenergetic diets for 4 wk each after being fed a 2-wk run-in diet (containing 34% of energy from fat). The experimental diets included a Step I diet, a low almond diet, and a high-almond diet, in which almonds contributed 0%, 10% and 20% of total energy, respectively.

Inverse relations were observed between the percentage of energy in the diet from almonds and the subject's total cholesterol (P value for trend <0.001), LDL-cholesterol (P <0.001), and apolipoprotein B (P <0.001) concentrations and the ratios of LDL to HDL cholesterol (P < 0.001) and of apolipoprotein B to apolipoprotein A (P <0.001). Compared with the Step I diet, the high-almond diet reduced total cholesterol (0.24 mmol/L or 4.4%; P = 0.001), LDL cholesterol (0.26 mmol/L or 7.0%; P <0.001), and apolipoprotein B (6.6 mg/dL or 6.6%; P <0.001); increased HDL cholesterol (0.02 mmol/L or 1.7%; P = 0.08); and decreased the ratio of LDL to HDL cholesterol (8.8%; P <0.001). Isoenergetic incorporation of ≈ 68g of almonds (20% of energy) into an 8368-kJ (2000-kcal) Step I diet markedly improved the serum lipid profile of heatlhy and mildly hypercholesterolemic adults. Total and LDL-cholesterol concentrations declined with progressively higher intakes of almonds, which suggests a dose-response relation.

Publications:
Jambazian PR, Haddad E, Rajaram S, Tanzman J, Sabaté J. Almonds in a diet simultaneously improve plasma alpha-tocopherol concentrations and reduce plasma lipids. J Am Diet Assoc, 2005;105:449-454.

Sabaté J, Haddad E, Tanzman JS, Jambazian P, Rajaram S. Serum lipid response to a graded enrichment of a Step I diet with almonds: a randomized feeing trial. Am J Clin Nutr, 2003, 77:1379-84. full text

Presentations:
Sabaté J, Haddad E. Almond-rich diets simultaneously improve plasma lipoproteins and alpha tocopherol levels in men and women. Poster presented at the 17 th International Congress on Nutrition. Vienna, Austria 2001. abstract

Jambazian P, Haddad E, Tanzman J, Sabaté J. Incorporating almonds in diet improves plasma alpha tocopherol levels. Experimental Biology ‘01. Orlando, FL, April 2001. abstract

Zemaitis J, Sabaté J. Effect of almond consumption on stool weight and stool fat. Experimental Biology ‘01. Orlando, FL. abstract

Sabaté J, Rajaram S, Jambazian P, Tanzman JS, Haddad E. Dose response effects of almonds on serum lipid levels in healthy men and women: a randomized feeding trial. Experimental Biology ‘01. Orlando, FL, April 2001. abstract

Sabaté J, Rajaram S, Jambazian, P, Myint T, Haddad E. Effects of almonds on serum lipids and fasting glucose levels in normocholesterolemic subjects. Experimental Biology ‘00. San Diego, CA, April 2000. abstract

Date: 1997

Funded by: Almond Board of California